How Physicochemical Properties Affect Drug Action: A Pharma Guide
by In the realm of pharmacology and drug design, physicochemical properties play a crucial role in determining a compound’s therapeutic potential. These properties affect a drug’s …
Category: Med. Chem-I (Unit 1)
Bioisosterism
Bioisosters are substituents or groups with similar physical or chemical properties that produce broadly similar biological properties to other chemical compounds. The relation between bioisosteres …
Drug metabolism or Bio-transformation
Drug metabolism refers to the biochemical processes by which the body chemically modifies pharmaceutical compounds to make them more water-soluble and easier to eliminate from …
Stereoisomerism of drugs
Stereochemistry involves the study of the three-dimensional nature of molecules. It is the study of the chiral molecules. Conformational Isomers: Different arrangements of atoms that …
PHYSIOCHEMICAL PROPERTIES IN RELATION TO BIOLOGICAL ACTION
The various physiochemical properties affecting the drug action are- 1. Ionization 5. Protein bonding 2. Solubility 6. Chelation 3. Partition coefficient 7. Bioisosterism …
Structure of Biological Membrane
The biological membrane (or cell membrane and plasma membrane) is a selectively permeable membrane that allows only certain substances to pass through it and acts …
HISTORY AND DEVELOPMENT OF MEDICINAL CHEMISTRY
Medicinal chemistry roots can be found in the fertile mix of ancient folk medicine and early natural product chemistry, hence its name. As appreciation for …
Agonist and Antagonist
An agonist and an antagonist are two types of molecules that interact with receptors in the body, but they have opposite effects on the receptor …
What is receptor?
A receptor is a specialized protein molecule, typically found on the surface of a cell or within its interior, that is capable of binding to …
Introduction to Medicinal Chemistry
Medicinal Chemistry is the branch of science that deals with the modification and synthesis of drug molecules. Or Medicinal chemistry is the chemistry discipline concerned …